Example of package parameters
package_parameters_example.RdAn example dataset of package parameters.
Format
A `data.frame` with the following variables:
- vnr
Package identifier of the purchased product, Nordic article number (Vnr) in this example (numeric)
- ATC
Anatomical Therapeutic Chemical (ATC) classification code (character)
- product_name
Product name (character)
- strength
Strength of drug in format register may deliver, including e.g. the drug strength and value type (e.g. mg) (character)
- strength_num
Numeric strength of drug, extracted from
strength(numeric)- packagesize
Package size in format register may deliver, including e.g. number and type of units (character)
- packsize_num
Number of units extracted from
packagesize(numeric)- drug_form_harmonized
Harmonized drug format (e.g. 'tabs' and 'pills' recorded as 'TABLET') (character)
- ddd_per_pack
Number of Defined Daily Doses (DDDs) in package (numeric)
- minimum_dur
Minimum duration of package (numeric)
- usual_dur
Usual duration of package (numeric)
- maximum_dur
Maximum duration of package (numeric)
- lower_ddd
Lower limit of daily dose of package as DDDs (numeric)
- usual_ddd
Usual daily dose of package as DDDs (numeric)
Details
PRE2DUP-R uses package-specific information to estimate drug exposure. Example parameters can be used as a template for creation of study specific package parameter file. PRE2DUP-R requires the package identifier, minimum, usual and maximum duration of the package, and daily dose's lower limit and the usual daily dose, both as daily DDDs. Other included information is for creating the required variables. See Package Parameters in Tutorials for more guidance.
See more about ATC classification at https://atcddd.fhi.no/atc/structure_and_principles/ and about DDDs at https://atcddd.fhi.no/ddd/definition_and_general_considera/.